 | Sai Yu Gou Ma Roku (Japan) (clone of: chinagat) | 1988 | Technos Japan | saiyugou | Platform / Fighter | 0.00 |
 | Saigo no Nindou (Japan) (clone of: nspirit) | 1988 | Irem | nspiritj | Fighter / 2D | 0.00 |
 | Scramble Spirits (Japan, Floppy DS3-5000-02-REV-A Based) (clone of: sspirits) | 1988 | Sega | sspiritj | | 0.00 |
| Scramble Spirits (World, Floppy Based) | 1988 | Sega | sspirits | Shooter / Flying Vertical | 7.00 |
| Scramble Spirits (World, Floppy Based, FD1094 317-0058-02c) (clone of: sspirits) | 1988 | Sega | sspirtfc | Shooter / Flying Vertical | 0.00 |
| | Secret Service (2.6) | 1988 | Data East | ssvc_a26 | | 0.00 |
 | Shadow Warriors (World, set 1) | 1988 | Tecmo | shadoww | Fighter / 2.5D | 5.00 |
| Shadow Warriors (World, set 2) (clone of: shadoww) | 1988 | Tecmo | shadowwa | Fighter / 2.5D | 0.00 |
 | Shanghai (Japan) | 1988 | Sunsoft | shanghai | Puzzle / Match | 3.00 |
 | Shingen Samurai-Fighter (Japan, English) | 1988 | Jaleco | tshingen | Fighter / Field | 6.20 |
 | Showdown (version 5.0) | 1988 | Exidy | showdown | Casino | 7.10 |
| | Sidewinder (Arcadia, set 1, V 2.1) | 1988 | Arcadia Systems | ar_sdwr | Unplayable | 0.00 |
| | Sidewinder (Arcadia, set 2) (clone of: ar_sdwr) | 1988 | Arcadia Systems | ar_sdwr2 | | 0.00 |
 | Silk Worm (Japan) (clone of: silkworm) | 1988 | Tecmo | silkwormj | | 0.00 |
| Silk Worm (World) | 1988 | Tecmo | silkworm | Shooter / Misc. Horizontal | 5.96 |
 | Sky Soldiers (US) | 1988 | Alpha Denshi Co. (SNK of America/Romstar license) | skysoldr | Shooter / Flying Vertical | 8.33 |
| | Snezhnaja Koroleva | 1988 | Terminal | koroleva | | 5.50 |
 | Space Harrier II (Mega-Tech) | 1988 | Sega | mt_shar2 | Shooter / Flying (chase view) | 0.00 |
| | Space Station (L-5) | 1988 | Williams | spstn_l5 | | 0.00 |
 | Splatter House (Japan) (clone of: splatter) | 1988 | Namco | splatterj | | 0.00 |
