 | Space Odyssey (version 2) (sample of: spaceod) | 1981 | Sega | spaceod | Shooter / Flying | 6.75 |
 | Space Seeker | 1981 | Taito Corporation | spaceskr | Shooter / Flying 1st Person | 7.50 |
 | Space Tactics | 1981 | Sega | stactics | Shooter / Gallery | 7.52 |
 | Spiders (set 1) | 1981 | Sigma Enterprises Inc. | spiders | Shooter / Gallery | 4.00 |
| Spiders (set 2) (clone of: spiders) | 1981 | Sigma Enterprises Inc. | spiders2 | Shooter / Gallery | 0.00 |
| Spiders (set 3) (clone of: spiders) | 1981 | Sigma Enterprises Inc. | spiders3 | | 0.00 |
| Spinner (clone of: spiders) | 1981 | bootleg | spinner | Shooter / Gallery | 0.00 |
| | Split Second | 1981 | Stern | splitsec | | 0.00 |
| | Star Raker (clone of: brdrline) | 1981 | Sega | starrkr | | 0.00 |
 | Star Trek (Defender bootleg) (clone of: defender) | 1981 | bootleg | startrkd | Shooter / Flying | 0.00 |
 | Stargate | 1981 | Williams / Vid Kidz | stargate | Shooter / Flying | 6.00 |
| | Status Black Jack (V1.0c) | 1981 | Status Games | statusbj | | 0.00 |
| | Status Fun Casino (V1.3s) | 1981 | Status Games | funcsino | | 0.00 |
 | Strafe Bomb (clone of: scramble) | 1981 | bootleg? (Omni) | strfbomb | Shooter / Flying Horizontal | 0.00 |
 | Strategy X | 1981 | Konami | stratgyx | Shooter / Driving Vertical | 6.32 |
| Strategy X (Stern Electronics) (clone of: stratgyx) | 1981 | Konami (Stern Electronics license) | stratgys | Shooter / Driving Vertical | 0.00 |
 | Super Astro Fighter (DECO Cassette) | 1981 | Data East Corporation | csuperas | Shooter / Gallery | 7.35 |
 | Super Cobra | 1981 | Konami | scobra | Shooter / Flying Horizontal | 5.78 |
| Super Cobra (bootleg) (clone of: scobra) | 1981 | bootleg | scobrab | Shooter / Flying Horizontal | 0.00 |
| Super Cobra (Sega) (clone of: scobra) | 1981 | Konami (Sega license) | scobrase | Shooter / Flying Horizontal | 0.00 |
